diff --git a/sentry_sdk/opentelemetry/span_processor.py b/sentry_sdk/opentelemetry/span_processor.py
index a148fb0f62..d70ae3dbe5 100644
--- a/sentry_sdk/opentelemetry/span_processor.py
+++ b/sentry_sdk/opentelemetry/span_processor.py
@@ -72,6 +72,7 @@ def on_start(self, span, parent_context=None):
             return
 
         self._add_root_span(span, get_current_span(parent_context))
+        self._add_origin(span)
         self._start_profile(span)
 
     def on_end(self, span):
@@ -98,6 +99,13 @@ def force_flush(self, timeout_millis=30000):
         # type: (int) -> bool
         return True
 
+    def _add_origin(self, span):
+        # type: (Span) -> None
+        if span.instrumentation_scope and span.instrumentation_scope.name:
+            span.set_attribute(
+                SentrySpanAttribute.ORIGIN, span.instrumentation_scope.name
+            )
+
     def _add_root_span(self, span, parent_span):
         # type: (Span, AbstractSpan) -> None
         """
diff --git a/sentry_sdk/opentelemetry/tracing.py b/sentry_sdk/opentelemetry/tracing.py
index 8392c1515a..3e3bbe556a 100644
--- a/sentry_sdk/opentelemetry/tracing.py
+++ b/sentry_sdk/opentelemetry/tracing.py
@@ -7,6 +7,7 @@
     SentrySampler,
     SentrySpanProcessor,
 )
+from sentry_sdk.utils import logger
 
 
 def patch_readable_span():
@@ -28,8 +29,21 @@ def sentry_patched_readable_span(self):
 
 def setup_sentry_tracing():
     # type: () -> None
-    provider = TracerProvider(sampler=SentrySampler())
-    provider.add_span_processor(SentrySpanProcessor())
-    trace.set_tracer_provider(provider)
+
+    # TracerProvider can only be set once. If we're the first ones setting it,
+    # there's no issue. If it already exists, we need to patch it.
+    from opentelemetry.trace import _TRACER_PROVIDER_SET_ONCE
+
+    if _TRACER_PROVIDER_SET_ONCE._done:
+        logger.debug("[Tracing] Detected an existing TracerProvider, patching")
+        tracer_provider = trace.get_tracer_provider()
+        tracer_provider.add_span_processor(SentrySpanProcessor())
+        tracer_provider.sampler = SentrySampler()
+
+    else:
+        logger.debug("[Tracing] No TracerProvider set, creating a new one")
+        tracer_provider = TracerProvider(sampler=SentrySampler())
+        tracer_provider.add_span_processor(SentrySpanProcessor())
+        trace.set_tracer_provider(tracer_provider)
 
     set_global_textmap(SentryPropagator())
diff --git a/sentry_sdk/tracing.py b/sentry_sdk/tracing.py
index 7a5f12fe91..f15f07065a 100644
--- a/sentry_sdk/tracing.py
+++ b/sentry_sdk/tracing.py
@@ -188,7 +188,7 @@ def __init__(
         If otel_span is passed explicitly, just acts as a proxy.
 
         If span is passed explicitly, use it. The only purpose of this param
-        if backwards compatibility with start_transaction(transaction=...).
+        is backwards compatibility with start_transaction(transaction=...).
 
         If only_if_parent is True, just return an INVALID_SPAN
         and avoid instrumentation if there's no active parent span.
diff --git a/tests/conftest.py b/tests/conftest.py
index d64652c4e9..04edaf4907 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -2,6 +2,8 @@
 import os
 import socket
 import warnings
+from opentelemetry import trace as otel_trace
+from opentelemetry.util._once import Once
 from threading import Thread
 from http.server import BaseHTTPRequestHandler, HTTPServer
 
@@ -73,6 +75,13 @@ def clean_scopes():
     setup_initial_scopes()
 
 
+@pytest.fixture(autouse=True)
+def clean_tracer():
+    """Reset TracerProvider so that we can set it up from scratch."""
+    otel_trace._TRACER_PROVIDER_SET_ONCE = Once()
+    otel_trace._TRACER_PROVIDER = None
+
+
 @pytest.fixture(autouse=True)
 def internal_exceptions(request):
     errors = []